The present study concerns development of high-strength low-carbon Cu-Ni-Ti-B multiphase steels in the as-hot-rolled condition. An attempt has been made to predict the microstructural evolution of the chosen steels during continuous cooling transformation by artificial neural network modeling as well as dilatometric study. Experimental results have demonstrated that direct air cooling of the hot-rolled Cu-Ni-Ti-B steel resulted in a microstructure containing intercritical ferrite and finer low-temperature transformation products of austenite. An attractive strength-ductility combination was achieved in the case of as-hot-rolled Cu-Ni-Ti-B steel with a dual-phase-like microstructure. Age hardening of the steels has further enhanced the mechanical properties. Analysis of the work-hardening behavior by differential Jaoult–Crussard (J-C) analysis has revealed the effect of aging on the work-hardening behavior.