A general procedure is presented for analyzing dynamic response measurements from complex multi-degree-of-freedom nonlinear systems incorporating arbitrary types of nonlinear elements. The analysis procedure develops a reduced-order, nonlinear model whose format is convenient for numerical simulation studies. No information about the system’s mass properties is needed, and only the applied excitations and corresponding response are needed to develop the model whose dimension is compatible with the number of available sensors. The utility of the approach is demonstrated by means of a three-degree-of-freedom system incorporating polynomial-type nonlinear features with hardening as well as softening characteristics.