The ability of sandwich panels to resist dynamic loading has been shown to be superior to monolithic metal plates of the same areal density by a number of investigators. Experimental and numerical studies on the response of sandwich panels to air-blast, water-blast and “simulated blast” are increasing, but mainly focus on the latter two. Three types of sandwich panels are identified, by core type: cellular core, micro-architectural core (small-scale lattice type) and macro-architectural core (larger scale plastic deforming elements). With advances in manufacturing techniques, several new core topologies have emerged which can allow core properties to be tailored according to design requirements (of which blast resistance may only be one factor), for example, lattice cores formed by selective laser-melting and metallic fiber cores. This chapter provides an overview on the state-of-the-art in the field of sandwich panel protection under blast and dynamic loading.