Addiction risk for opioids in painful patients needs to be considered. Using screening tools is useful for assessing opioid addiction. Main tools are presented: Portenoy’s and Savage’s criteria, 4CS, ORT, SOAPP-R, STAR, PMQ, CAGE-AID, Michna’s questionnaire, ABC, POMI. Reasons for this interest are questioned. Recommendations concerning addiction risk are proposed with main questions before and during opioid treatment. Alert flags should be proposed: green (low risk), orange (high risk), red (present problem) to help clinicians looking for the assistance of pain, addiction or mental health professionals.