The ability to access the normal pericardium in the absence of any effusion induced increasing interest in the pericardial space as a location of and novel approach for various cardiac and intrapericardial applications. Intrapericardial drug delivery may be superior to other routes in special indications. Medication applied intrapericardially will maintain the effective concentration for a longer time. Drugs given in the pericardial space may access the vessel wall and the myocardial tissue directly for a much longer time, but also more predictably and consistently than by an intracoronary or intravenous injection [1]. The intrapericardial route might have additional important advantages for the application of pharmacological agents like an easier access to perivascular tissue.