This study uses a computer model to simulate a quadrupole mass filter (QMF) instrument under different operating conditions for Mathieu stability zones 1 and 3. The investigation considers the factors that limit the maximum resolution (Rmax), which can be obtained for a given QMF for a particular value of scan line. Previously, QMF resolution (R) has been found to be dependent on number (N) of radio frequency (rf) cycles experienced by the ions in the mass filter, according to R = N n /K, where n and K are the constants. However, this expression does not predict the limit to QMF resolution observed in practice and is true only for the linear regions of the performance curve for QMF operation in zone 1 and zone 3 of the stability diagram. Here we model the saturated regions of the performance curve for QMF operation in zone 1 according to R = q(1 – 2c N )/∆q, where c is a constant and ∆q is the width of the intersection of the operating scan line with the stability zone 1, measured at q-axis of the Mathieu stability diagram. Also by careful calculations of the detail of the stability tip of zone 1, the following relationship was established between Rmax and percentage U/V ratio: R max = q/(0.9330-0.00933U/V). For QMF operation in zone 3 the expression R = a – bc N simulates well the linear and saturated regions of the performance curve for a range of operational conditions, where a, b, and c are constants.