An equivalent linear substructure approximation of the soil–foundation–structure interaction is proposed in this paper. Based on the inherent linearity of the approach, the solution of the structural and the soil domain is obtained simultaneously, incorporating the effects of the primary and secondary soil nonlinearities. The proposed approximation is established theoretically and then validated against centrifuge benchmark soil–foundation–structure interaction tests. The equivalent linear substructure approximation is proved to simulate efficiently the effects of the nonlinear soil behavior on the soil–foundation–structure system under a strong earthquake ground motion.