Magnitude comparison of single digits is robustly characterized by a distance effect (close numbers are more difficult to compare than numbers further apart) and a size effect (for a given distance, comparison difficulty increases with increasing size). The distance effect indicates access to the mental number line (Dehaene, 1997), and the size effect is usually interpreted as indicating that the mental number line represents larger numbers more vaguely than smaller ones. In contrast, we have argued earlier (Verguts, Fias, & Stevens, 2005) that for symbolic numbers (Arabic or verbal notation), the size effect does not originate from the mental number line but, instead, originates from mappings to relevant output components that are specific for magnitude comparison. If the latter is true, it should be possible to dissociate the distance effect from the size effect in tasks other than magnitude comparison. In two experiments, we observed a robust distance effect insame/different judgments, which implies access to the mental number line. Yet the size effect was absent. Consistent with our prediction, this finding establishes a dissociation between the size effect and the distance effect.