Individualized treatment planning, monitoring, and follow-up in oncology rely on accurate staging. Given the potential of a systemic spread, the examination of the whole body is crucial to correctly assess most malignant diseases. Whole-body MRI fulfils these needs since new technological developments enable MRI to image the entire body in state-of-the-art quality in a single examination. In a modular concept, individual examination protocols can be compiled using components of a set of various body part-adapted sequence protocols. Thus whole-body MRI can contribute to individualized medicine for oncological patients by tailoring the examination to the specific clinical question and clinical situation, taking into account individual patient and disease characteristics.