The new data obtained during thorough geological-structural, geochronological, petrographic, and petrochemical investigations of Late Cretaceous granitoids from the southern Sredinnyi Range in Kamchatka and zircon dating by the U-Pb SIMS and LA-ICPMS methods indicate that this region was characterized by intense granitoid magmatism in the Campanian (83.1 ± 2.0 to 76.2 ± 1.5 Ma). The Campanian granitoids mark initiation of the “newly formed” continental crust in Kamchatka. The composition of these Late Cretaceous rocks demonstrates similarity to peraluminous I-type granites. The data allow the Campanian stage of magmatic activity to be defined in southern Kamchatka.