Proxy Mobile IPv6 (PMIPv6) is an effective mobility management protocol for next generation wireless networks which improves ubiquitous network access. However, PMIPv6 still suffers from lengthy handover latency and packet loss during the handover when Mobile Host moves to a new network. In order to improve the performance of PMIPv6, we proposed an integrated solution scheme with Media Independent Handover (MIH) and neighbor discovery message of IPv6 to reduce handover latency and packet loss. The proposed protocol does not have method to prevent from security threats such as replay attack and key exposure when mobile host first enters in PMIPv6 domain. In order to address this problem, we proposed one-time key with Diameter Message authentication framework which is based on the one-time key generation authentication protocol. It is expected the proposed framework is able to enhance security as well as reduce authentication latency.