Objective: Optimal tracheobronchial stenosis treatment in esophageal cancer remains a clinical challenge.Methods: Subjects were 26 patients with tracheobronchial stenosis due to esophageal cancer treated by modalities such as expandable metallic stent emplacement, laser therapy, radiotherapy, and/or chemotherapy. We assessed patient outcome and modality efficacy, and determined prognostic factors for survival using multivariate analysis.Results: Of the 26, 16 (61%) had improved respiration after treatment. Average post-treatment survival was 140 days (10–1550 days). Multivariate analysis indicated that a Karnofsky performance score of ≥70% was the most significant prognostic factor, with chemotherapy and laser therapy also significant factors.Conclusions: Although individual modalities were effective in ameliorating respiratory symptoms, patients with good performance status survived the longest. After a tracheobronchial stenosis diagnosis in esophageal cancer patients, chemotherapy and laser therapy are recommended if the patient is in good general condition.