Business process design is an integral part of e-business engineering. Given that e-business models usually involve a wide range of business processes across different business functions with complex activities, events, and documents, process design for e-business is a very challenging task. Although various process reference models (PRMs) have been developed to provide guidelines for process design, research on leveraging multiple PRMs to support process design for e-business has been scant. In this paper, we demonstrate that the diverse process design requirements in e-business are best satisfied by utilizing multiple PRMs via a case study. Then, we propose a collaborative approach grounded in knowledge management theory to integrating multiple process reference models to better support process design in e-business. We equip the integrated process repository with a set of novel features based on Web 2.0 technologies to enhance its utility, efficiency, and quality for process design support. A prototype system is developed and user experiments are conducted to evaluate the system.