We investigate Atiyah algebroids, i.e. the infinitesimal objects of principal bundles, from the viewpoint of the Lie algebraic approach to space. First we show that if the Lie algebras of smooth sections of two Atiyah algebroids are isomorphic, then the corresponding base manifolds are necessarily diffeomorphic. Further, we give two characterizations of the isomorphisms of the Lie algebras of sections for Atiyah algebroids associated to principal bundles with semisimple structure groups. For instance we prove that in the semisimple case the Lie algebras of sections are isomorphic if and only if the corresponding Lie algebroids are, or, as well, if and only if the integrating principal bundles are locally isomorphic. Finally, we apply these results to describe the isomorphisms of sections in the case of reductive structure groups—surprisingly enough they are no longer determined by vector bundle isomorphisms and involve dive rgences on the base manifolds.