This chapter introduces a number of new gene–environment interaction measures and develop novel statistics that are based on these new gene–environment interaction measures. These new statistics are simple, less computationally intensive and easy to implement. It is hoped that these developments may open a new avenue for large-scale genome-wide gene–environment interaction analysis, deciphering the genetic and physiological meaning of gene–environment interactions and developing sophisticated statistical methods for unraveling gene–gene and gene–environment interactions leading to the development of human cancers.