Using a sample of 144 mature students, aged 18–53 years, attending a high school upgrading program, the screening properties of the Holden Psychological Screening Inventory (HPSI) and the correspondence of the HPSI to the Basic Personality Inventory (BPI) were evaluated. Correlations between the HPSI and the BPI scales and joint factor analysis of these two inventories demonstrated the validity of HPSI scales and their sampling adequacy from the major components of psychopathology measured by the BPI. Using the BPI as the “Gold Standard,” the HPSI has almost perfect specificity but the sensitivity of the HPSI is only about 50% at a T-score of 60, whereas at T = 55, the sensitivity is 70%, with a specificity of almost 80%. Overall, results indicated that the three HPSI scales distinctly measure the three major factors of the BPI, and the HPSI has considerable utility as a screening tool.