We design a multi-layer cladding large-core planar waveguide that supports a single guided mode. The waveguide works on the principle of higher-order mode discrimination. The cladding of the waveguide is formed by alternate low- and high- index regions, which helps leaking out of higher-order modes while retaining the fundamental mode over the entire length of the waveguide. The structure is analyzed by the transfer-matrix method and the leakage losses of the modes have been calculated. We show that a waveguide formed in silica with numerical aperture 0.24 and core width 10 μm can be designed to exhibit single-mode operation at 1550-nm wavelength. Such a structure should find applications in high-power planar waveguide lasers and amplifiers.