Density Functional Theory (DFT) calculations of infrared spectra for the optimized geometries of the R-(+)-3-methylcyclopentanone (R3MCP) equatorial-methyl and axial-methyl conformers were performed in eleven common solvents with a wide polarity range, within the framework of polarizable continuum model (PCM). The DFT correlation function type B3LYP, using a powerful basis set (aug-cc-pVDZ), yielded different linear correlations between solvent polarity and R3MCP equatorial and axial conformers for frequencies of IR modes, intensities, and enthalpies. DFT calculations of the dipole moments of R3MCP equatorial and axial conformer components in 3D were also carried out and found to have a linear correlation with the solvent polarity. An increasing trend for the hypsochromic (blue) shift in the equatorial conformer’s IR frequencies is observed, in comparison to bathochromic (red) shift for the axial-methyl conformer IR modes, as a function of the solvent polarity.