Embedded system software development is challenging, owing to a tight integration of the software and its physical environment, profoundly impacting the software technology that can be applied for constructing embedded systems. Modeling and model-based design are central to capture all essential aspects of embedded systems. Vanderbilt University’s Model Integrated Computing tool suite, driven by the recognition of the need for integrated systems and software modeling, provides a reusable infrastructure for model-based design of embedded systems. The suite includes metaprogrammable model-builder (GME), model-transformation engine (UDM/GReAT), tool-integration framework (OTIF), and design space exploration tool (DESERT). The application of the MIC tool suite in constructing a tool chain for Automotive Embedded System (VCP) is presented.