Interaction of ribonucleotides, namely 5′-AMP, 5′-GMP, 5′-CMP, and 5′-UMP with copper chromicyanide has been studied. Maximum adsorption was observed at neutral pH. The adsorption isotherms were found to be Langmuirian in nature. Copper chromicyanide was found to be effective adsorbent and purine nucleotides showed more adsorption than pyrimidine nucleotides. Infrared spectral studies suggested that the adsorption occurs due to interaction of phosphate moiety, N-1, N-3, and N-7 of ribonucleotide molecule and outer divalent copper ion present in the lattice of copper chromicyanide. Copper chromicyanide also has been found to be efficient in catalyzing the conversion of cysteine into cystine. The results of the present study support the hypothesis that the metal cyanogen complexes could have played important role in concentrating and stabilizing the biomonomers on their surfaces during the course of chemical evolution and could have acted as prebiotic catalyst.