Anterior knee pain is a common complaint and reason for people to seek orthopedic medical care, in either a general or sports medicine practice. It affects a wide range of patients, from highly competitive athletes to the aging population. Despite its prevalence, however, anterior knee pain remains a poorly understood entity that has not been well studied in the literature. “Anterior knee pain” is a nonspecific term that can result from a host of etiologies, including malalignment, muscular imbalance, overuse, trauma, and biochemical substance changes. Although these are all reasonable causes of pain, we have found that unilateral anterior knee pain can oftentimes simply be attributed to asymmetry between the knees.