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Cellular senescence is an irreversible proliferation arrest with emerging physiological roles in tumor suppression and tissue wound repair. For example, primary cells that acquire a first oncogenic event often enter cellular senescence and this serves to block their further proliferation and neoplastic transformation. As cells become senescent, the spectrum of factors secreted by those cells changes...
The new millennium brought multiple discoveries of epigenetic events regulating the chromatin structure of normal and cancerous cells. Such renewed enthusiasm for chromatin studies was prompted by the development of new technologies and novel ideas that helped discover the “histone code.” It is now clear that posttranslational modifications of histone tails and insertion of histone variants regulate...
Senescence is observed in both human and mouse cells, however, there are fundamental differences in how senescence is controlled between the two species. Human fibroblasts undergo replicative senescence as a result of telomere shortening. In contrast, mouse fibroblasts do not senesce when grown at a physiological oxygen concentration. In atmospheric oxygen, mouse cells enter a state that resembles...
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