In this post-genome era, structural and functional biology is playing an increasingly important role in Life Science research and development. Transforming current bio education for future research biologists is therefore a challenging task. Learning structural biology starting from K-12 year or in pre-university education is an issue of strategic importance. This paper presents our experimental work on bio edutainment for structural biology learning in secondary schools. Through playing, students will have a more intuitive way to understand better bio-molecular structures. Immersive and interactive games may potentially motivate students to explore the wonders of Life Science. The bio edutainment solution developed is powered by the Virtual Reality technology.