In the broadest sense, health disparities are inequities or inequalities in environment, access and utilization of care, health status, and health outcomes (Carter-Pokras and Baquet 2002). These inequalities can occur at any stage of the cancer continuum (prevention, incidence, etiology, screening, diagnosis, access to clinical trials, treatment, survival, morbidity, and mortality) (Krieger 2005). Another chapter in this monograph (Chapter 14) addresses community-based approaches for cancer disparities. This chapter reviews current knowledge about effective interventions to reduce cancer disparities, particularly with respect to policy and advocacy, and recommends strategies for implementing and sustaining these interventions. While there may be some necessary overlap in the approaches described in the two chapters, they complement one another to provide an array of possible interventions.