This study of the cult of Asklepios reveals that happiness, well-being, and health were inseparable from and unified with devotion and religion in the healing arts practiced in the Asklepieia of antiquity. Religion, the tie that binds together a community, was the ultimate means to attain health for the suppliants of the Asklepieia scattered across the ancient Mediterranean world. A brief review of the cult of Asklepios and its health centers and practices, with some insights from the work of Kerényi, Meier, the Edelsteins, and others, will illuminate the mental-health aspects of the cult and foreshadow some additional insights into this intriguing union of religion and health.