Fetal membranes are essential for the maintenance of sterile intrauterine milieu for proper fetal growth and development. Chronic infection and inflammation may lead to progressive stretching, hardening of the membranes, making them less elastic and more susceptible to premature rupture of membranes (PROM). PROM is associated with fetal morbidity and mortality which is inversely proportional to the period of gestation. Amniopatch even though still in experimental stages to be an established treatment for PROM, is a formidable treatment modality which has shown to seal the chorioamniotic leak and prolonging the pregnancy with improved fetal outcome. With increasing intrauterine fetal interventions both diagnostic (amniocentesis) and therapeutic (fetoscopy), amniopatch is an option for persistent amniotic fluid leakage which has shown to effectively seal the chorioamniotic leak in about two-third of the cases.