Manganese oxides (MnO x ) were prepared by spray pyrolysis methods (Mn S ) and calcination at 600 and 1,000 °C (Mn600 and Mn1000) in this study. Further, the efficiencies of oxidizing isopropanol (IPA) by these MnO x utilizing ozone (OZCO) and thermal catalytic oxidation (TCO) were compared. The results indicated that Mn S , which are characterized by larger surface areas, processed gas hourly space velocity of 42,000 h−1 and inlet IPA concentration of 400 ppm performing IPA decomposition efficiencies approaching 100%, and the reaction temperature was operated at only 85 °C for OZCO. The reaction temperature of TCO operated above 270 °C decomposed IPA at the same efficiency.