TOPCARES-CDIO is based on the CDIO engineering education concept and with characteristics of Dalian Neusoft Institute of Information (Dalian Neusoft II) application-oriented personnel training mode, which attaches great importance to enhance the ability of students. College Students Entrepreneurial Center (Student Office & Venture Office, hereinafter referred to as SOVO) is Dalian Neusoft II has created a groundbreaking IT Talents Cultivation Base in China’s colleges, which combined with a new educational philosophy and engineering education mode. Compared with some foreign countries, Chinese students’ entrepreneurship education is still relatively backward. This paper combines the opportunities and status of Chinese college students’ entrepreneurship education and career guidance, corresponding to Dalian Neusoft II the actual characteristics, developed a suitable college student and effective new model, which is the construction of engineering education business practice base based on TOPCARES-CDIO. For the reform of SOVO practice teaching base, it conducted in-depth study and research, highlighting introduces SOVO based on TOPCARES-CDIO engineering education philosophy, working to enhance the ability of students carried out important reforms.