Stereotactic Radiosurgery (SRS) is a method of precisely delivering high doses of radiation to destroy targeted areas of abnormal tissue. Stereotactic Radiosurgery (SRS) and Stereotactic Radiotherapy (SRT) are effectively being used in the treatment of arteriovenous malformations (AVM), trigeminal neuralgia (TN), and malignant or benign brain tumors, while minimizing the amount of radiation delivered to surrounding normal tissue (Khan 2003). Over 50 years ago the first trigeminal neuralgia case was treated radiosurgically by Lars Leksell (Leksell 1951). Leksell developed the SRS procedure to destroy dysfunctional loci using Orthovoltage X-rays, and particle accelerators. He subsequently introduced the Gamma Knife™ (Elekta, Stockholm, Sweden) device using 60Co sources (Leksell 1968). Linear Accelerator (LINAC) based SRS technique was first proposed by Borje Larsson in 1974 (Larsson et al. 1974). This technique is based on methods of geometric superposition, using at least 300° of multiple non-coplanar arcs converged at the target to give a spherical dose distribution with rapid dose fall-off. LINAC-based SRS systems, such as the X-knife™ (Radionics, Burlington, MA, USA) system, are more common than Gamma Knife systems, and can be less expensive. The clinical differences between Gamma Knife systems and LINAC-based systems are insignificant. Both systems use stereotactic frames for immobilization and localization. The frame-based procedure involves placement of a stereotactic frame on the patient’s skull, localization of the target coordinates using an imaging technique, treatment planning, and finally the treatment delivery. There are two advantages to the frame-based SRS technique, i.e., sub-millimeter geometric accuracy of treatment delivery system, and high conformity with steep dose gradients. Various SRS techniques have been developed and clinically used. These include Gamma Knife, LINAC-based SRS, frameless SRS3 (Cyberknife®, Novalis® Radiosurgery), and charged particle accelerators such as proton beam SRS (Khan 2003).