The discovery of abrupt paleo-climate change events and the prediction of environmental changes in the future time have raised an urgent request for high-resolution paleo-environmental records. This paper reviews the progress made in chronology and paleo-environment of stalagmites from karst caves in China and presents some of the results of TIMS-U-series dating of stalagmites composed of secondary carbonates, taken from the Dongge, Longquan and Yamen karst caves in Libo County and the Qixing karst cave in Duyun, Guizhou Province, on a MAT-262 mass spectrometer.