The paper reports about a detailed investigation of the methods of design of sequences of monomer units in copolymers with special emphasis on biomimetic approaches. The main objective of the described approach is to formulate new methods of synthesis of copolymers with sophisticated functional properties. In particular the design of protein-like copolymers is performed by computer simulation. The properties of these copolymers are compared with those of random and block copolymers having the same overall composition by the Montecarlo method using the bond fluctuation model. Experimental approaches aimed to obtain these protein-like copolymers carried out in various laboratories are finally reported.
Key words: Protein-like copolymers, MonteCarlo calculations, coil-globule transition, .monomer sequences, globule formation, computer simulation