Exercise prescription for patients with diabetes follows guidelines regarding frequency, intensity, duration, and mode of exercise established for patients participating in a medically supervised exercise program. Physicians and health care professionals should devise an exercise care plan that maximizes the benefits and minimizes the risks for each patient. The distinction between prescribing exercise for patients with T1DM and patients with T2DM with and without DRCs is reviewed. The question whether to exercise or not based on hyperglycemia /hypoglycemia is presented. It is highly recommended that health care professionals incorporate progressive resistance training and lifestyle-based physical activity into the exercise prescription for patients with diabetes. Health care professionals should be knowledgeable about diabetic medications to avoid the potential for hypoglycemia associated with exercise.