The protolytic properties of 2-dialkylaminomethylphenols were characterized by effective partition constants in the tetrachloromethane-water medium at 298 K by means of two-phase potentiometric titration. A correlation was found between the effective partition constant including the dissociation constant of the protonated form of 2-dialkylaminomethylphenol and the π constants of the substituents. The partition constants of the compounds were calculated. The formation of 1:1 charged copper(II) complexes in aqueous solution and of 2:1 neutral complexes in the organic phase was revealed. The stability constants of the complexes in aqueous solution and the partition constants of the 2:1 complexes were estimated.