Regional networking can help companies to gain competitive advantage, provided that the network is actively coordinated and managed. For this purpose, cluster initiatives aiming at delivering potentials for success for their members arouse in many regions in previous years. Based on literature, this article analyzes the different stages of development of a cluster initiative and the specific tasks of the cluster management in these stages. Applying the relational and the resource-based view, we explain possible company’s competitive advantages resulting from cooperation. Subsequently, we distinguish each stage and describe the specific tasks of the different protagonists of a cluster. Finally, we discuss these theoretic findings of how to develop cluster initiatives and their applicability by a case study of the HESSENMETALL Cluster Initiative and derive implications for science and management.