AbstractNew amineptine hydrochloride (Am-Cl) ion-selective electrodes (conventional type) based on amineptinium-tetraphenylborate (I) and amineptinium-phosphomolybdate (II) were prepared. The electrodes exhibited mean slopes of calibration graphs of 57.9mV and 53.8mV per decade of (Am-Cl) concentration at 25C for electrodes (I) and (II), respectively. The electrodes can be used within the concentration range 3.16105102M (Am-Cl) at a pH range of 2.03.9 for both electrodes. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coefficients of the electrodes, which were 0.00172VC1 and 0.00091 VC1 for (I) and (II) electrodes, respectively. The electrodes showed a very good selectivity for (Am-Cl) with respect to a number of inorganic cations and sugars. The standard addition method is successfully applied to determine (Am-Cl) in pure solutions and in amineptine-containing tablets.