New surveys with the Spitzer space telescope identify distant starburst and active galaxies by their strong emission at far-infrared (IR) wavelengths. Using deep Spitzer surveys at 24 and 70µm coupled with HSTimaging in the Chandra Deep Field South, we study the relation between galaxy morphology and IR-active stages of galaxy evolution. IR-luminous galaxies span a wide range of morphology. At z ∼ 1, there is a correlation between the relative fraction of galaxies with morphological distortions (multiple nuclei, tidal tails, etc.) and increasing IR luminosity, which suggests that the strong starbursts at high redshift arise from galaxy interactions. However, the majority of IR-luminous galaxies do not have exceptionally asymmetric morphologies, and galaxies with strong asymmetries correspond to a range of galaxy IR activity. We conclude that the relation between galaxy morphology and IR activity is highly complex, and strongly dependent on the initial conditions of galaxy interactions.