For decades, barium fluoroscopy studies have been the standard of reference to investigate small bowel diseases. Since the small bowel was not accessible to endoscopic techniques, these studies represented the only non-invasive diagnostic approach to the intestine. Both bowel follow-through and small bowel enteroclysis yielded fairly good results, with sensitivities and specificities of, respectively, 98.3% and 99.3% for Crohn’s disease (CD) [1] and 61–95% for neoplastic disease [2], notably in the assessment of the intestinal mucosa due to the high spatial resolution obtained with these techniques. However, their limitations are that they provide almost exclusively intraluminal information and are associated with considerably high radiation exposure, up to 10–18 mSv. The technical advances in cross-sectional imaging achieved with computed tomography (CT) and magnetic resonance imaging (MRI) over the past 10 years have tremendously improved image quality in the abdomen, thus encouraging small bowel imaging.