In the last few years a new paradigm has emerged in science: extensively use of simulation techniques and software modeling, running on a distributed high performance computing electronic infrastructure. This paradigm is referred to as electronic Science or e-Science. Besides computer simulation, it uses huge amounts of distributed and shared data captured by instruments or sensors and/or stored in databases, analyzed to provide new results for science. This distributed HPC and data ecosystem enables the sharing of acquired knowledge, remote access to resources and above of all a world-wide scientific collaboration.