We examined how relationships among intrapersonal (i.e., attitudes and beliefs about smoking) and ecodevelopmental (i.e., family, school, and peer) factors influence risk for lifetime smoking in immigrant Hispanic adolescents. Our sample was comprised of 223 immigrant Hispanic adolescents and their families and was drawn from 3 middle schools in a single school district. Data collected is a result of adolescent and parent completed questionnaires as well as county school data (i.e., GPA, teacher reported effort and conduct, absences). Results indicated only poor school functioning, peer smoking, and lack of perceived harm concerning smoking were directly related to adolescent lifetime smoking. Poor school functioning and peer smoking mediated the relationship between family functioning and adolescent smoking. Implications of these results for the design of smoking preventive interventions for immigrant Hispanic adolescents are discussed.