Background. The purpose of this study was twofold: to test the hypothesis that religious and spiritual beliefs provide medical outpatients with a system of meaning and existential understanding, and to seek to determine some elements that constitute the domain of spiritual and religious beliefs as they relate to subjective well-being. Methods. The Spiritual Well-Being Scale (SWBS) questionnaire was administered to a convenience sample of adult outpatients. Results. Patients agreed, strongly to moderately, with statements that had a direct reference to God having a significant influence (cares about me, concerned about my problems, contributes to my sense of well-being) on the daily life of the respondent. Conclusion. Religious and spiritual beliefs provide medical outpatients with a system of meaning and existential understanding. Outpatients identified with more cognitive rather than affective perceptions of well-being, in addition to a conceptualization of what a loving God may mean.