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Hypothermia is a tool providing cerebral protection in the management for traumatic brain injury and cardiovascular bypass surgery. However, alteration in vasodilatory function of cerebral pial arteriole under hypothermic conditions is not fully understood. We examined the cerebrovascular response to topically administered vasodilators under normo-and hypothermic conditions. All animals were anesthetized...
Recently our group demonstrated, in rats, that moderate hypothermia followed by gradual rewarming exerted significant cerebrovascular-protection when assessed up to 6 h following traumatic brain injury (TBI). However, as these studies were confined to the acute postinjury period, we questioned whether this same cerebrovascular protection persisted with more prolonged survival. To explore this issue...
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