We summarize the strengths and limitations of currently available multiple-scale techniques, where the emphasis is made on the latest prospective approaches, such as the bridging scale method, multiscale boundary conditions, and multiscale fluidics. Example problems, in which multiple-scale simulation methods yield equivalent results to full atomistic simulations at fractions of the computational cost, are shown. We conclude by discussing future research directions and needs in multiple-scale analysis, and also discuss the ramifications of the integration of current nanoscale research into education.