An experimental study has been conducted to investigate the flow around two identical square cylinders in tandem arrangement and placed near a plane wall at a Reynolds number of 6,300. The inter-cylinder spacing ratio was varied from S * = 0.5 to 6, and the cylinder-to-wall gap ratio from G * = 0.25 to 2. Totally, 42 cases were considered to systematically examine the effects of wall proximity and the mutual interference between the two cylinders in the normalized gap–spacing (G *–S *) plane. The flow fields were captured using digital particle image velocimetry, in conjunction with measurements of the fluid forces (drag and lift) acting on the downstream cylinder using a piezoelectric load cell. The results show that the flow is highly dependent on the combined values of G * and S *. Categories relating to G * could be broadly classified as small-gap regime (G * < 0.5) at which periodic vortex shedding from the cylinders is suppressed, intermediate-gap regime (0.5 < G * < 1) where vortex shedding occurs but is under the influence of the wall proximity, and large-gap regime (G * > 1) where the wall effects become negligible. Similarly, the flow interference between the two cylinders can be divided into three basic categories as a function of S *, namely, shielding regime at S * < 1, reattachment regime at 1 < S * < 3, and impinging regime at S * > 3. Variations of force coefficients, amplitude spectra, Strouhal numbers, and Reynolds shear stress with G * and S * are presented to characterize the different flow regimes.