The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The population of HIV-infected adults is progressively aging, due to more effective treatments that lower the viral load. Since aging and HIV disease each have major detrimental effects on the immune system, it is possible that in older persons who are infected with HIV-1, the immune changes due to the infection combined with those that occur with age may synergize to exacerbate the disease. Indeed,...
It is well-known that infections and sepsis are increased in elderly subjects, and that the immune system changes with age. The question arises whether dysfunctionality of the immune system, or immunosenescence, contributes to this increased incidence of infections and if so, how. As the immune system evolved to protect against infection, the role of aging is likely to be important for the increased...
Increasing age is associated with a decline in adaptive immunity and poorer responses to vaccination. While specific immune defects have clearly been defined in the naïve T-cell pool of aged individuals, much less is known about the memory T-cell pool. Current data suggest that T-cell memory generated in an aged individual has a reduced capacity to mediate recall responses due primarily to defects...
Since its discovery in 1983, HIV-1 has become the most extensively studied pathogen in history. Massive CD4+T-cell depletion and sustained immune activation and inflammation are hallmarks of HIV-1 infection. However, the precise pathway to the onset of immunodeficiency that develops during HIV-1 infection has not been resolved yet. In recent years, an intriguing parallel between HIV-1 infection and...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.