Abstract The Manila clam Ruditapes philippinarum, an intertidal bivalve, was exposed to different salinity regimes (from 31.031.7 down to 20, 15, 10, 5), and the endogenous rhythm in its oxygen consumption was studied using an automatic intermittent-flow respirometer. When exposed to salinities reduced from 31.5 to 20 and 15 under otherwise constant conditions, the clams recovered a clear endogenous circatidal rhythm in their oxygen-consumption rate after having dampened periods of 12h and 48h, respectively. At salinities less than 10, however, the oxygen-consumption rate was depressed greatly at the beginning of the experiment for about 36h and then increased to a level higher than normal, but the rhythm of oxygen consumption was not recovered. The results of this study indicate that the Manila clam, a euryhaline organism, cannot maintain a normal metabolic activity at a salinity lower than 15. All clams were dead after exposure at a salinity of 5 for 7days.