We describe a simple protocol to achieve homonuclear J-decoupling in the indirect dimensions of multidimensional experiments, and to enhance spectral resolution of the backbone Cα carbons in the 3D NCACX experiment. In the proposed protocol, the refocusing of the Cα–CO homonuclear J-couplings is achieved by applying an off-resonance selective π pulse to the CO spectral region in the middle of Cα chemical shift evolution. As is commonly used in solution NMR, a compensatory echo period is used to refocus the unwanted chemical shift evolution of Cα spins, which takes place during the off-resonance selective pulse. The experiments were carried out on the β1 immunoglobulin binding domain of protein G (GB1). In GB1, such implementation results in significantly reduced line widths, and leads to an overall sensitivity enhancement.