Models capable of predicting the product quality of sweet potato chips have been developed using response surface methodology and used to determine the optimum processing conditions. Moisture loss, oil uptake, crispness (measured using a bending-snapping test in the TA.XT2 Texture Analyser), and sensory attributes such as colour, flavour, and texture were used to assess the product quality in the preparation of sweet potato chips. The optimum conditions which were attained for maximum moisture loss (11.65% on wet basis), minimum oil uptake (2.57%), crispness (794.37g), colour score (7), flavour score (7) and texture score (7) were: frying temperature, 174.7C; salt concentration, 0.45%; citric acid concentration, 0.37%; potassium metabisulphite concentration, 0.65%; and frying time, 26s.