The issues of poor health care, poverty, crime, and HIV infection make it more difficult for minority communities to combat substance abuse and other diseases that are prevalent in the African-American community. Faith communities in general, and African-American churches in particular, are a largely untapped, but potent, resource to reduce the toll of substance abuse and other health issues. Information about ministers' knowledge, attitudes, and behaviors regarding leading health indicators, the frequency with which they discuss these issues from the pulpit, and organizational readiness to develop and implement interventions can be the foundation of clergy training and health intervention efforts.