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The carcinoembryonic antigen (CEA) family comprises a large number of cellular surface molecules, the CEA-related cell adhesion molecules (CEACAMs), which belong to the Ig superfamily. CEACAMs exhibit a complex expression pattern in normal and malignant tissues. The majority of the CEACAMs are cellular adhesion molecules that are involved in a great variety of distinct cellular processes, for example...
Nectins are Ca2+-independent immunoglobulin-like cell-cell adhesion molecules which constitute a family of four members. Nectins homophilically and heterophilically trans-interact and cause cell-cell adhesion. This nectin-based cell-cell adhesion plays roles in the organization of adherens junctions in epithelial cells and fibroblasts and synaptic junctions in neurons in cooperation with cadherins...
Cell adhesion molecules of the immunoglobulin superfamily (IgSF CAMs) were discovered 25 years ago based on their role in cell-cell adhesion. Ever since, they have played a major role in developmental neuroscience research. The elucidation of IgSF CAM structure and function has been tightly linked to the establishment of new areas of research. Over the years, our view of the role of the IgSF CAMs...
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