Intravesical electromotive administration of local anesthetics is clinically successful but electrochemistry, cost and effectiveness limit the choice of drugs to diluted lidocaine HCl 4% mixed with epinephrine. These studies address the stability of lidocaine and epinephrine both over time and when exposed to electric current, i.e. transport rates with passive diffusion and electromotive administration. The drug mixture used was 50ml lidocaine 4%, 50ml H2O and 1ml epinephrine 1/1000. For stability, the solution was placed either in bowls for 7days or in a two chamber cell with the donor compartment (drugs) separated from the receptor compartment (NaCl solution) by a viable pig bladder wall. This was subjected to 30mA for 45min. Stability was measured with mass spectrometry. The cell was also used to determine transport rates with passive diffusion and currents of 20mA and 30mA, over 20, 30 and 45min. Drug measurements in both compartments and bladder were made with HPLC. Lidocaine remained stable throughout the 7days, epinephrine on day1 only and both drugs were stable with 30mA for 45min. Comparing 20mA and 30mA with passive diffusion, there were significant differences in 6/6 donor compartment lidocaine levels, 4/6 receptor compartment levels and 6/6 bladder tissue levels and also in 6/6 epinephrine donor levels and 6/6 tissue levels. The combination lidocaine and epinephrine remains stable for 1day and when exposed to 30mA for 45 min. Electric current accelerates the transport of lidocaine and epinephrine.